This block includes integrated topics from Biochemistry, Physiology, Microanatomy, Pharmacology and Pathology. The course begins with an introduction to cell structure and function, examining the details of the plasma membrane, cytoskeletal structure and cell organelles. This material includes integrated information about the molecular structure of amino acids, proteins, enzymes and lipids and functional considerations for cell-to-cell communications. It also includes a discussion of the basic tissue types and an introduction to pathologic changes which may affect them. The final portion of this course is dedicated to a discussion of molecular human genetics. The concepts of carcinogenesis, mutagenesis and genetic alteration, as well as an introduction to antineoplastic agents and gene therapy strategies, conclude the material to be presented.
Cellular and Molecular Biology
This block includes integrated topics from Biochemistry, Physiology, Microanatomy, Pharmacology and Pathology. The course begins with an introduction to cell structure and function, examining the details of the plasma membrane, cytoskeletal structure and cell organelles. This material includes integrated information about the molecular structure of amino acids, proteins, enzymes and lipids and functional considerations for cell-to-cell communications. It also includes a discussion of the basic tissue types and an introduction to pathologic changes which may affect them. The final portion of this course is dedicated to a discussion of molecular human genetics. The concepts of carcinogenesis, mutagenesis and genetic alteration, as well as an introduction to antineoplastic agents and gene therapy strategies, conclude the material to be presented.
Schedule
Unit 1
8-10 Orientation (Chakraborty)
10-12 Cell Intro (Chakraborty)
1-3 Proteins I (Williams)
8-10 Cell Motility (Crissman)
10-12 TCA Cycle (Manning)
1-3 Micro Lab Epithelial Tissue
8-10 Proteins II (Williams)
10-12 Plasma Membrane I (Smas)
1-3 Epithelial Tissues (Crissman)
8-10 Cell Cycle (de la Serna)
10-12 TCA Cycle II (Manning)
1-3 Micro Lab Connective Tissue
8-10 PBL
10-12 Cytoskeleton/nucleus (Chakraborty)
1-3 Connective Tissue (Crissman)
8-10 PBL
10-12 Myoglobin/Hemoglobin (Dignam)
1-4 Lab Quiz, Review, Q&A (Crissman)
8-10 Plasma Membrane II (Smas)
10-12 Blood (Chakraborty)
1-3 Micro Lab Cytology
8-10 Myoglobin/Hemoglobin, etc. (Dignam)
10-12 Electron Transport (Manning)
1-3
8-10 Mitochondria (Jacobus)
10-12 Proteins III (Williams)
1-3 Peer Mentoring Groups
8-10 Enzymes (Dignam)
10-12 Carbohydrates (Manning)
1-3 Review Vocab - what-where-why - Unit One.xls
Vocab - what-where-why - Unit One.csv
around 144 questions
Unit 2
LABOR DAY
8-10 Muscle 1 (Chiaia)
10-12 Gluconeogenesis (Manning)
1-3 Micro Lab Bone Development
UNIT 1 EXAM
8-10 Muscle 2 (Chiaia)
10-12 Lipid Beta Oxidation (Maltese)
1-3 Glucogen Metabolism (Manning)
8-10 PBL
10-12 Glycolysis (Manning)
1-3 Cartilage (Crissman)
8-10 PBL
10-12 Muscle 3 (Chiaia)
1-3 Review (Manning)
8-10 Bone (Crissman)
10-12 Pentose Phosphate Pathway (Manning)
1-3
8-10 Neurocellular Structure (Chiaia)
10-12 Fatty Acid Synthesis (Maltese)
1-3 Muscle 4 (Lee)
8-10 Bone Development (Crissman)
10-12 Interconversion of Hexoses (Manning)
1-3 Micro Lab Cartilage & Bone
8-10 Micro Lab Muscle and Nerve
10-12 Triacylglycerols (Maltese)
1-3 Lab Quiz, Intervention
Vocab 1.2.xls
Manning:
Vocab 1.2 Week 4.xls
(Has Chiaia muscle and neuro vocab only,
no lipids or Dr. Lee)
around 120 questions
Unit 3
UNIT 2 EXAM
8-10 Coronary Heart Disease (Trumbly)
10-12 Cell Signalling (Sanchez)
1-3 FCP
SELF-STUDY
8-10 Amino Acids 2 (Dignam)
10-12 Dyslipidemia, Therapy (Trumbly)
1-5 Mandatory FCP Skill Session
8-10 PBL
10-12 Phospholipids, Sphingolipids,
Arachidonic Acid (Maltese)
1-4 FCP Orientation
8-10 PBL
10-12 RBC Metabolism 1 (Dignam)
1-3 Mandatory FCP Ethics
8-10 Cholestrol and Steroids (Maltese)
10-12 LIpid Digestion and Transport (Trumbly)
1-3 FCP
8-10 RBC Metabolism (Dignam)
10-12 Clinical Nutrition (Boardley)
1-5 Mandatory FCP Skill Session
8-10 Amino Acids 1 (Dignam)
10-12 Lipoprotein Metabolism (Trumbly)
1-3 FCP
8-10 Heme Metabolism, Bile (Dignam)
10-12 FCP
1-3 Intervention
RBC Metabolism Outline
8-10 RBC Disorders (White)
10-12 Weight Management (Boardley)
1-3
8-9 Heme Disorders (White)
9-10 Metabolic Syndrome/Diabetes (Trumbley)
10-12 FCP
1-5 Mandatory FCP Skill Session
8-10 PBL
10-12 Case Studies (White)
1-5 Mandatory FCP Skill Session
8-10 PEM, Vitamins (Boardley)
10-12 Hemostasis and Bleeding (Smith)
1-3
8-10 Case Studies (Smith)
10-12 Review (Trumbly)
1-3 Intervention
around 117 questions
Unit 4
UNIT 3 EXAM
8-10 DNA Replication 2 (Dignam)
10-12 RNA Transcription 1 (Ratnam)
1-5 Mandatory FCP Skill Session
8-10 Nucleotide Metabolism 1 (Trumbly)
10-12 Meiosis and Gametogenesis (Chakaborty)
1-3 FCP
8-10 RNA Transcription 2 (Ratnam)
10-12 Mendelian Inheritance (Cicila)
1-5 Mandatory FCP Skill Session
8-10 PBL
10-12 Nucleotide Metabolism 2 (Trumbly)
1-3 FCP
8-10 PBL
10-12 Protein Translation (Ratnam)
1-3 Mandatory FCP Ethics
8-10 Nucleic Acid (Dignam)
10-12 Chromosome Structure (Chakaborty)
1-3 FCP
8-10 Molecular Medicine (Micale)
10-12 Clinical Cytogenetics (Micale)
1-3
8-10 DNA Replication 1 (Dignam)
10-12 Folates and B12 (Trumbly)
1-3 Intervention
8-10 Recombinant DNA Tech (Trempe)
10-12 Multifactorial Inheritance (Cicila)
1-3 Intervention
8-10 Genome Imprinting, Disomy, Disorders (Joe)
10-12 Gene Therapy
1-3 FCP
8-10 Immunogenetics (Lee)
10-12 Molecular Basis of Disease (Cicila)
8-10 Inborn Errors of Metabolism (Saad)
10-12 Population Genetics (Cicila)
1-3 FCP
STUDY DAY
8-10 PBL
10-12 Congential Abnormalities (Self-study)
1-3 FCP Ethics in Genetics
UNIT 4 EXAM
8-10 Genetic Diseases (Self-study)
10-12 Mitochondrial Disorders,
Genetic Linkage Analysis (Cicila)
1-3 FCP Ethics in Genetics
COMPREHENSIVE EXAM
8-10 Dysmorphology (Saad)
10-12 Pharmcogenetics, Review (Cicila)
1-3 Intervention
BLOCK 2 BEGINS
around 144 questions
75 Questions
Final Exam Review Materials
Old Exams
Unit 1
Unit 2
Unit 3
Unit 4
Old Material
Unit 3
Unit 4
Units 1-4
2006 Block 1